隨著載人航天事業(yè)的發(fā)展，空間站的建立，月球計劃、火星計劃等逐步推進，航天員在空間環(huán)境中的時間日益延長, 但是否能順利適應(yīng)太空環(huán)境仍是目前面臨的一個重要問題，因此解決外太空微重力環(huán)境、空間輻射及密閉空間等導致機體發(fā)生的一系列問題顯得尤為重要。

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參考文獻：

[1] 茍鴻蒙 胡瑜 楊春. 微重力對人類細胞影響的研究進展[J]. 醫(yī)學綜述， 2018, (7): 1279-1288.

[2] Otsukak, CornelissenG, KuboY, etal, Erratum: lntrinsic cardiovascular autonomic regulatory system of astronauts exposed longterm to micro-gravity in space: Observational study [J]. NPJ Micro-gravity, 2016, 2: 16037

[3] Crucian B, Sams C. lmmune system dysregulation during space flight: Clinical risk for exploration-class missions [J]. J Leukoc Biol, 2009, 86 (5): 1017-Ｊ101

[4] Matsumoto A, Storch KJ, Stolfi A, et a l. Weight loss in humans in space[J] . Aviat Space Environ Med, 2011, 82 (6):615-621.

[5] Allen DL, Bandstra ER, Harris on BC, et al. Effects of spaceflight on murine skeletal muscle gene expression[J]. JAppl Physiol (1985), 2019, 106 (2):582-595.

[6] Norsk P. Cardiovascular and fluid volume control in humans in space[J]. Curr Pharm Biotechnol, 2005, 6 (4):325-330.

[7] Buckey JC jr, Lane LD, Levine BD, et al. Orthostatic intolerance after spaceflight [J]. Appl Physiol (1985), 1996, 81 (1):7-18.

[8] 湯納平, 李華, 邱云良, 等．微重力對血管及血管內(nèi)皮細胞的影響[J]. 生理科學進展，2014, 45 (5):385-390.

[9] Infanger M, Kossmehl P, Shakibaei M, et al. Induction of three-dimensional assembly and increase in apoptosis of human endo-thelial cells by simulated microgravity: Impact of vascular endo-thelial growth factor [J]. Apoptosis, 2006, 11 (5):749-764.

[10] Infanger M, Ulbrich C, Baatout S, et al. Modeled gravitational unloading induced downregulation of endothelin-1 in human endo-thelial cells [J]. J Cell Biochem, 2011, 101 (6):1439-1455.

[11] Griffoni C, Di Molfetta S, Fantozzi L, et al. Modification of pro-teins secreted by endothelia cells during modeled low gravity exposure[ j ]. J Cell Biochem, 2011, 121 (1) :265-272.

[12] Ma X, Sickmann A, Pietsch J, et al. Proteomic differences between microvascular endothelial cells and the EA. hy926 cell line form-ing three-dimensional structures[J]. Proteomics, 2014, 14 (6) :689-698.

[13] 石菲．回轉(zhuǎn)模擬失重對靜脈內(nèi)皮細胞血管生成能力的影響及信號轉(zhuǎn)導機制研究［Ｄ]. 西安：第四軍醫(yī)大學，2012.

[14] Sun Z, Cao X, Hu Z, et al. MiR-103 inhibits osteoblast prolifera-tion mainly through suppressing Cavl, 2 expression in simulated microgravity[J]. Bone, 2015, 76:121-128.

[15] Sun Z, Cao X, ZhangZ, et al. Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts[J]. Sic Rep, 2015, 5:8077.

[16] Yan M, Wang Y, Yang M, et al. The effects and mechanisms of clinorotation on proliferation and differentiation in bone marrow mesenchymal stem cells[J]. Biochenm Biophys Res Commun, 2015, 460 (2):327-332.

[17] Hu Z, Wang Y, Sun Z, et al. miRNA-132-3p inhibits osteoblast differentiation by targeting Ep300 in simulated microgravity[J]. Sci Rep, 2015, 5:18655.

[18] Meyers VE ,Zayzafoon M, Douglas JT, et al. RhoA and cytoskele-tal disruption mediate reduced osteoblastogenesis and enhanced adipogenesis of human mesenchymal stem cells in modeled microgravity[J]. J Bone Miner Res, 2005, 20 (10):1858-1866.

[19] Bradamante S, Barenghi L, Maier JA. Stem cells toward the future: The space challenge[J]. Life (Basel), 2014, 4 (2):267-280.

[20] Dai Z, Wu F, Chen J, et al. Actin microfilament mediates osteoblast Cbfal responsiveness to BMP2 under simulated microgravity[J]. PLoS One, 2013, 8 (5):e63661.